1. What is Retatrutide?

Retatrutide is a triple agonist peptide, targeting GLP-1, GIP, and glucagon receptors.

Unlike Ozempic or Mounjaro (which are dual agonists), Retatrutide’s triple mechanism helps:

- Suppress appetite

- Improve insulin sensitivity

- Increase energy expenditure

- Reduce visceral fat

- Support lean muscle retention

It’s being hailed as the “miracle molecule” by high-performance biohackers and longevity doctors.

2. How is Retatrutide Used?

• Dosage: Currently studied at doses ranging from 0.5mg to 12mg weekly. Start low and titrate up slowly.

• Administration: Subcutaneous injection, once weekly, or can be micro-dosed 2 to 3x week.

• Cycle Length: 12 to 24 weeks is typical for fat loss cycles.

• Monitoring: Regular bloodwork to track glucose, insulin, liver enzymes, and hormone panels is recommended.

3. Who Should (and Shouldn’t) Use It?

✅ Good Fit If You:

• Are 15–25+ kgs overweight

• Struggle with insulin resistance or stubborn fat

• Want to preserve lean muscle during a cut

• Already have sleep, training, and nutrition dialed in
  

🚫 Not For You If You:

• Are underweight or prone to muscle loss

• Have poor sleep, zero training, and no nutrition habits

• Expect it to fix everything without changing your lifestyle

4. Dieting While on Retatrutide

The molecule reduces appetite significantly — so you must be strategic.

Goal: Eat high-quality, nutrient-dense foods that maintain muscle, support hormones, and fill micronutrient gaps.

🥩Macros & Guidelines:

• Protein: 1-1.5g per kg of goal bodyweight (minimum)

• Fats: 0.3–0.5g per kg of bodyweight

• Carbs: Fill the rest based on insulin sensitivity and activity levels

• Meal Frequency: 2–3 meals/day works well for satiety and compliance
  

Focus on:

• Grass-fed beef, eggs, chicken, fish

• Vegetables, berries, avocado, fermented foods

• Low-toxin carbs like white rice, sweet potatoes, oats
  

Avoid:

• Ultra-processed foods, seed oils, refined sugar, synthetic sweeteners

5. Training on Retatrutide

You’ll likely have lower appetite and possibly reduced energy during initial weeks. So training must be smart and intentional.

🏋️ Strength Training (3–4x per week):

• Focus on compound lifts: squats, deadlifts, presses, rows

• Use moderate-to-heavy weights (5–10 reps per set)

• Limit volume. Intensity > Duration.

🏃 Conditioning (1–2x per week):

• HIIT sprint sessions (10–15 min max)

• Rucking, incline walks, sled pushes

🚶 Daily Movement:

• 8–12k steps per day minimum

• Walks after meals to improve glucose control

6. Sleep & Recovery

Your results depend heavily on recovery.

Retatrutide works better when cortisol is low and circadian rhythm is locked in.

Do this:

• 7–9 hours of sleep per night

• Morning sunlight within 30 minutes of waking

• No caffeine after 2 PM

• Stop screens 90 min before bed

Use magnesium glycinate, glycine, or apigenin before bed if needed.

7. Common Side Effects & How to Avoid Them

• Nausea or vomiting → Start at a low dose and never inject on an empty stomach

• Constipation → Drink 3–4L water/day, add magnesium citrate or fiber like Psyllium

• Low energy → Ensure electrolytes, salt, and potassium intake are adequate

• Muscle loss → Don’t crash diet. Keep protein high and train hard.

9. Final Note

Retatrutide isn’t magic.

But when paired with the right lifestyle?

It’s a nuclear weapon for fat loss and metabolic optimization.

This isn’t about relying on drugs.

It’s about building a bulletproof base — and then stacking smart compounds to unlock elite results.

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